Effects of Cheonwangbosim-dan in a Mouse Model of Chronic Obstructive Pulmonary Disease: Anti-Inflammatory and Anti-Fibrotic Therapy

Chronic obstructive pulmonary disease (COPD) is a lung illness, marked by dyspnea, coughing, and sputum production. Cheonwangbosim-dan (CBD) traditional East Asian medicine, consisting of combination 15 medicinal herbs, which frequently used to treat arterial/auricular flutter, neuroses, cardiac-malfunction-induced diseases, insomnia. The present study evaluated the therapeutic effect CBD (100 or 200 mg/kg) on COPD using mouse model induced cigarette smoke (CS) lipopolysaccharide (LPS). increase in inflammatory cell numbers caused exposure CS LPS was significantly reduced administration. In addition, therapy interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α) bronchoalveolar lavage fluid (BALF). tissue, not only levels IL-1β (CBD 100: p < 0.001 200: 0.001), IL-6 TNF-α = 0.005 0.014), monocyte chemoattractant protein-1 (MCP-1; 0.018 0.003), but also decreased expression α-smooth muscle actin (α-SMA; transforming growth factor-β (TGF-β; matrix metallopeptidase-7 (MMP-7; 0.019 MMP-9 0.015 0.013), tissue inhibitor metalloproteinase-1 (TIMP-1; 0.035 0.013) compared with group. found suppress phosphorylation nuclear factor kappa B (NF-κB), extracellular signal-regulated kinase 1/2 (ERK1/2), p38 mitogen-activated protein kinases (p38 MAPK). Taken together, these findings showed that can attenuate respiratory inflammation airway remodeling LPS, suggesting has probable preventive applications patients COPD.